Strontium-doped calcium polyphosphate (SCPP) which were a series of calcium polyphosphate (CPP) respectively containing 0,1,2,5,8,10 mol% of Ca2+ replaced by Sr2+ used as a novel bone material were prepared. The influence of SCPP on cellular behavior and angiogenic factors which were vascular endothelial growth factor (VEGF) and basic fibroblastic growth factor (bFGF) of osteoblasts was investigated, which provides experimental basis for elucidating mechanism of SCPP promoting vascularization. Osteoblasts were cultured with SCPP scaffolds, XRD, MTT assay, quantitative detection of ALP activity, scanning electron microscopy (SEM) observation, Reverse Transcription-Polymerase Chain Raction (RT-PCR) analysis and Enzyme-linked Immunosorbent Assay (ELISA) were used to investigate. The results showed that, compared with the control, the cellular proliferation, ALP activity as well as the mRNA and protein expression of the angiogenic factors (VEGF and bFGF) of the SCPP group were significantly promoted (p
