In order to increase image registration accuracy in change detection, from the view of multi-scale fusion,a method was proposed for region variation detection,which applied the multi-scale analysis to remote sensing image.First of all, Wavelet transform was adopted to decompose original images, then Mahalanobis distance decision function was used to detect the changes of different scale images, and finally Markov random field was applied to fuse different scale change detection results. Since Markov random field fusion method took full account of the correlation between the adjacent pixels and the links of different scale change detection results, the fusion results were more accurate and practical. The testing results showed that this method is effective and robust.