To increase antibody generating speed in artificial immune system, a chaos negative selection algorithm was presented which is based on the chaotic character of immune system. Over spread character of chaos sequence was used to generate candidate set of detector firstly, and then the chaos disturbance was used to get some individuals directly and reduce search space, additionally chaos initial value sensitivity was used to overcome redundancies. The experimental results showed that the algorithm noy only retains the diversity of population but also increases the generating efficiency of detector.