Hydroxypropyl chitosan (HPCTS) with good water-soluble was synthesized through modified chitosan, which is pre-basified with propylene epoxide in the isopropanol solvent. The properties of HPCTS were studied. The results showed that HPCTS with degree of substitution(DS)≥0.40, is dissolved completely in water over pH=1~13, and has higher moisture absorption; and moisture retention than CTS in the same condition, and has good antibacterial effect as CTS.