FEZF1在结直肠癌组织和癌旁正常组织中的表达及临床意义
The expression and clinical significance of FEZF1 in colorectal cancer tissues and adjacent normal tissues
作者：李宗鑫(四川大学生命科学学院 功能基因组实验室)；贺正池(四川大学生命科学学院 功能基因组实验室)；肖雪薇(四川大学生命科学学院 功能基因组实验室)；罗玉(四川大学生命科学学院 功能基因组实验室)；兰洋(四川大学生命科学学院 功能基因组实验室)；吴传芳(四川大学生命科学学院功能基因组实验室)
Author：LI Zong-Xin(Department of Functional Genome, College of Life Sciences, Sichuan University)；HE Zheng-Chi(Department of Functional Genome, College of Life Sciences, Sichuan University)；XIAO Xue-Wei(Department of Functional Genome, College of Life Sciences, Sichuan University)；LUO Yu(Department of Functional Genome, College of Life Sciences, Sichuan University)；LAN Yang(Department of Functional Genome, College of Life Sciences, Sichuan University)；WU Chuan-Fang(Department of Functional Genome, College of Life Sciences, Sichuan University)
收稿日期：2018-04-09 年卷（期）页码：2019,56(2):338-344
期刊名称：四川大学学报: 自然科学版
Journal Name：Journal of Sichuan University (Natural Science Edition)
关键字：Fez家族锌指蛋白1; 结直肠癌; 增殖; 迁移
Key words：FEZF1; Colorectal cancer; Proliferation; Migration
基金项目：国家自然科学基金（31300674）
中文摘要
本文旨在探究FEZF1蛋白在结直肠癌组织和癌旁组织中的表达和其临床意义.通过免疫组化实验和Western Blot实验以及细胞实验,发现FEZF1在结直肠癌组织中低表达,并且其表达与肿瘤淋巴结转移(tumor node metastasis,TNM)分期具有显著相关性,在FEZF1低表达时,RKO细胞增殖和迁移能力提高,FEZF1高表达时RKO细胞增殖能力减弱.本研究证明了FEZF1是结直肠癌中的一个低表达蛋白,其表达与结直肠组织癌变的发生、发展相关,并且FEZF1会抑制结直肠癌细胞的增殖和迁移.
英文摘要
We explore the expression and clinical significance of FEZF1 protein in colorectal cancer tissues and adjacent tissues.In this paper, immunohistochemistry, Western Blot and cell experiments showed that FEZF1 was down-regulated in colorectal cancer tissues, and its expression was significantly correlated with tumor node metastasis (TNM) stage. When FEZF1 was low expressed, the proliferation and migration ability of RKO cells increased, and the proliferation ability of RKO cells decreased when FEZF1 was highly expressed. This study demonstrates that FEZF1 is a low-expression protein in colorectal cancer, its expression is associated with the occurrence and development of colorectal cancer, and FEZF1 inhibits the proliferation and migration of colorectal cancer cells.
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