高通量抗体芯片研究AILD血清炎性因子表达特征
Detection of serum cytokines of autoimmune liver disease patients by high throughput cytokine antibody microarray
作者：张茂(电子科技大学 医学院)；房俊(四川省医学科学院•四川省人民医院医学实验中心)；张剑波(四川省医学科学院•四川省人民医院医学实验中心)；汪智英(四川省医学科学院•四川省人民医院医学实验中心)；曹玫(电子科技大学 医学院;四川省医学科学院•四川省人民医院医学实验中心)
Author：ZHANG Mao(School of Medicine, University of Electronic Science and Technology)；FANG Jun(Core Laboratory, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital)；ZHANG Jian-Bo(Core Laboratory, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital)；WANG Zhi-Ying(Core Laboratory, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital)；CAO Mei(School of Medicine, University of Electronic Science and Technology;Core Laboratory, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital)
收稿日期：2017-11-17 年卷（期）页码：2018,55(5):1103-1108
期刊名称：四川大学学报: 自然科学版
Journal Name：Journal of Sichuan University (Natural Science Edition)
关键字：细胞因子抗体芯片；自身免疫性肝炎；炎性因子；肝功能
Key words：Cytokine antibody microarray; Autoimmune hepatitis; Inflammatory factor
基金项目：四川省卫生和计划委员会基金（120092）
中文摘要
利用微阵列抗体芯片技术检测53例自身免疫性肝病（AILD）患者血清中20种辅助性T细胞相关炎性因子的表达水平，结合肝功能临床生化数据，分析炎性因子的表达特征和差异性.高通量抗体芯片检测结果显示：AIH-PBC OS患者血清中IL 4和TGFβ1表达量水平显著高于PBC组（P
英文摘要
The antibody microarray technique was used to detect the expression of 20 kinds of helper T cell associated inflammatory cytokines in serum of 53 patients suffered with autoimmune liver disease (AILD). Combining with the clinical biochemical data of liver function to analyze the expression characteristics and differences in inflammatory factors in serum of patients with autoimmune liver disease (AILD). The results showed that the levels of IL 4 and TGFβ1 in serum of patients with AIH-PBC OS were significantly higher than those of PBC (P
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