Objective To observe the effect of treatment of Polyactin A in the patients with recurrent oral ulcer (ROU). Methods Oral Polyactin A and local apply Polyactin A, observe clinical symptom and immunological indexes, and analyse results of experiment. Results Indexes of cellular and bodily immunity were not normal. After treatment of Polyactin A, the indexes were restoration. Conclusion Polyactin A was role on improvement of immunological function in the patients with ROU.