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论文摘要

口腔鳞状细胞癌间质成纤维细胞α-SMA的表达及意义

Study on Expr ession of a Smooth Muscle Actin in Stromal Fibroblasts of Or al Squamous Cell Car cinoma

作者:郑华1,申俊1,高庆红2,吴兰雁3,周红梅1

Author:ZHENG Hua1, SHEN Jun1, GAO Qing- hong2, WU Lan- yan3, ZHOU Hong- mei1 .

收稿日期:          年卷(期)页码:2007,34(03):157-159

期刊名称:国际口腔医学杂志

Journal Name:International Journal of Stomatology

关键字:口腔鳞状细胞癌,α-平滑肌肌动蛋白,波形蛋白,癌相关成纤维细胞,

Key words:oral squamous cell carcinoma,α- smooth muscle actin,vimentin; carcinoma- associated fibroblasts,

基金项目:

国家自然科学基金资助项目(30572035);四川省科技攻关资助项目(05SG022- 018- 1)

中文摘要

目的 探讨口腔鳞状细胞癌( OSCC) 间质成纤维细胞中α- 平滑肌肌动蛋白( α- SMA) 的表达水平及意义。方法 收集新鲜OSCC 组织标本34 例, 以正常口腔黏膜( 5例) 、口腔扁平苔藓( 6 例) 和口腔白斑组织( 9例) 为对照, 在冰冻切片上行α- SMA 和波形蛋白免疫组化染色( SP法) 。结果 OSCC 组α- SMA 的平均染色分值和染色阳性标本百分率均高于对照组( P

英文摘要

Objective To study the expression of α- SMA in stromal fibroblasts of different pathological grades of OSCC. Methods Fresh specimen of 34 cases of OSCC and 20 cases of controls(including 5 cases of normal oral mucosa, 9 cases of oral leukoplakia and 6 cases of oral lichen planus)were collected and made into freezing slides. The immunohistochemistry was used to detect the expression of α- SMA and vimentin. Results The mean percentage of positive cases and staining score of α- SMA in OSCC group were higher than control group with statistical significance(P

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