Objective To observe clinic curative effect on treating serious periodontitis with BAM artificial bone by periodontal guided bone regeneration(PGBR) technique in one year. Methods 45 patients with serious periodontitis, total 67 diseased teeth, were selected from outpatient department for treating with BAM artificial bone by PGBR technique after finishing basic therapy. Clinic curative effects were evaluated after complete therapy 6 and 12 months through rule clinic and X- ray examination. Results Periodontal pocket deep(PD), gingiva blood index(GBI), teeth move(TM) and alveolar bone height(AH) of 67 diseased teeth except for 5 removed after treating 6 and 12 months improve much more than before treating. Conclusion PD, GBI, TM and AH of diseased teeth treating with BAM artificial bone evidently improved after finishing therapy one year in our study.