Cyclin D1 ( CCND1) is a key regulator in the cell cycle. Overexpression of CCND1 protein significantly correlated with the development, progression and prognosis of various tumors. Recently, ccnD1 gene A870G polymorphism has been identified at nucleotide A870G. In this paper, the association of CCND1 A870G polymorphism with the development and progression of tumors is reviewed.