Tumor necrosis factor receptor-associated factor nuclear factor-κB-binding kinase 1（TBK1） are already proved to play an important role in mediating immune responses to DNA vaccines, not only adaptive immune responses including cellular immunity and humoral immunity, but also innate immune responses. Recently, it is reported that stimulator of interferon genes（STING） is a significant element for the production of typeⅠinterferon to regulate innate immunity, which is mediated by TBK1. In this review, the role of TBK1 mediated immune responses to DNA vaccines and the role of STING gene mediated innate immune responses to TBK1 were introduced.
