Oral cancer is the most common neoplasm of the head and neck. Patients with oral cancer show elevated prevalence rates of mood disorder. Mood disorder is a kind of‘catalyst’in the development of cancer and the prognosis predictor. Mood disorder in oral cancer may be associated with circadian disruption in hypothalamic-pituitary-adrenal（HPA） axis. Based on this analysis, we recommend that alteration of circadian rhythm of the HPA axis may play a crucial role in biology mechanism of intervention on oral cancer with mood disorder.
