With modern medical mode to biological—psychological—social model transformation, the effect of the social psychological factors on etiology of dental caries has been constantly highlighted. The social psychological factors can increase the sensitivity of dental caries in the way of increasing the amount of the hormone and immunotransmitter, reducing immune defenses by the nerve—endocrine—immune network, such as reducing production of saliva, changing the velocity of flow and the components of saliva. The result induces or increases the etiology of dental caries. In this article the research progress about social psychological factors on dental caries so that oral doctors can realize the effect of psychosocial factors on dental caries to improve prevention and treatment level to these diseases.