Malignant tumors have been a hazard factor to the mental and physical health of human beings. The key to improve curing effectiveness rely on early detection, early diagnosis and early treatment. It is generally recognized to use serum as a common measure to have a minimally invasive examination. Being a complementary method of proteomics, serum peptidomics maintain a character of simple structure, less than 1.0 ×10 4 molecular weight, high specialty and easy for synthetize, which arouse the academic and medicine attention in clinical proteomics at present. This article intends to review the research progression of serum peptidomics on biomarkers discovery in malignant tumors.
