Stem cells research has grown exponentially owing to their ability to rescue and repair injured tissue and partially restore organ function. The dental stem cells are considered rich sources of mesenchymal stem cells that are suitable for tissue engineering applications. These stem cells have the potential to differentiate into several cell types, including odontoblasts, neural progenitors, osteoblasts, chondrocytes and adipocytes. The dental stem cells exist widely in dental tissues, including dental pulp, periodontal ligament, dental papilla, and dental follicle. Technologies using dental stem cells might be a new model of renewal medicine.