Integrin-αvβ6is a special integrin subtype, which highly express in cancer and healing wound, but did not express in normal tissue and benign tumor. By promoting tumor cell migration and extracellular matrix degradation, activating cytokine transforming growth factor-β1and inhibiting tumor cell programmed cell death lead to tumor invasion and metastasis. Further study of integrin-αvβ6expression and function in oral cancer will help to understand the molecular mechanisms of invasion and metastasis, provide oral squamous cell carcinoma treatment with new ideas and methods.
