ObjectiveTo detect the expression of Ezrin in oral squamous cell carcinoma（OSCC）, paratumor tissue and normal tissue and to probe the relationship between OSCC in the process of development and the role of lymph node metastasis.MethodsDetecting the patients which did not receive radiotherapy and chemotherapy, including 50 cases with OSCC surgical resection specimens, 15 specimens of paratumor tissue, and 15 specimens of normal tissue. Serial sections of the blocks or microarrays were stained with immunohistochemical SP methods using mouse anti human monoclonal antibodies against Ezrin. Using semi -quantitative integration method to determine the outcomes, which were statistical analysed, and conclude finally.Results1）The positive rates of Ezrin were 26.67%, 53.34%, 78.00% in normal tissue, paratumor tissue and OSCC, respectively（P＜0.05）. 2）The expresion of Ezrin were increased gradually in OSCC, paratumor and normal tissue, one adjacent OSCC and paratumor tissue, paratumor tissue and normal tissue, OSCC and normal tissue between the expression of difference was significant（P＜0.05）. 3）The expression of Ezrin correlated with lymph node metastasis（P＜0.05）, not with histological grade（P>0.05）.Conclusion 1）Ezrin may play an important role in the development of OSCC. 2）Detection of OSCC tissue Ezrin expression levels may contribute to OSCC with lymph node metastasis is a potential forecast. 3）The expression of Ezrin in OSCC correlated with lymph node metastasis, not with histological type.
