Periodontal disease is a common and infectious non-nasal disease that directly affects oral health. Periodontal disease has been confirmed to be the vital reason that causes adults to lose teeth. Discussing its pathogenesis and studying the pathology characteristics, curative effect, and clinical observation is not enough because of the complexity of the clinical manifestations of periodontal disease. Therefore, animal models have been widely applied. In recent years, canine models are widely used in studies on periodontal disease. This review will illustrate the status of these studies.