Objective To compare and study the colorimetry and transparency of Vita In-Ceram YZ and Sirona InCorisZI to divect clinical repair. Methods Six groups of Vita In-Ceram YZ samples were made. Five groups of samples were immersed in the Vita In-Ceram YZ staining fluid(LL1-LL5), and the other group was the control. Five groups of Sirona InCorisZI samples were made. After sintering, the final thickness of samples was 0.5 mm. The chromatic value(L*, a*, b*) and integral visible light transmittance ratio(τ) of the 11 groups’ samples were measured. Results With increasing label number, the values of L* and τ decreased both in Vita and Sirona zirconia ceramic. Among Vita groups, there were significant differences(τ) between Vita0 and Vita3, Vita4, and Vita5. Significant differences were also found between Vita1 and Vita3, Vita4, and Vita5. Among sirona groups, significant differences(τ) were found between Sirona4.5 and Sirona0.5, Sirona1, and Sirona2. Between the same and similar label numbers of Vita and Sirona zirconia ceramic, no significant difference was found in terms of the τ value. Moreover, the ΔE was more than 2 NBS between the two groups, except for the Sirona4.5 and Vita4 groups. Conclusion In Vita groups or Sirona groups, the τ value may differ according to the different label numbers. Between the same or similar label numbers of the two groups, no difference was found in terms of the τ value. However, a difference in ΔE was found. High transparency zirconia materials that can better reproduce the color of teeth should be chosen for applications.