Objective To evaluate the influence of psychological health education on the effect of maxillofacial prosthesis. Methods A total of 46 patients who received maxillofacial prosthesis were randomly divided into two groups, namely, the experimental group(n=23) and the control group(n=23). Only patients in experimental group received psychological health education. Satisfaction on maxillofacial prosthesis among the patients in the two groups was compared on the 1st and 3rd months after prosthesis. Results Compared with control group, the satisfaction of experimental group was higher on the 1st and 3rd months after prosthesis, especially satisfaction with mastication, speaking, stability, and deglutition(P