ObjectiveTo observe fenestration and decompression technique in the treatment of unicystic ameloblastoma while observing the efficacy of the method in preserving the mandibular second molar.MethodsUnicystic ameloblastoma of six patients was treated using fenestration and decompression technique and tumor removal surgery while preserving the mandibular second molar. The patients were followed up for 1 to 5 years.ResultsEight months after decompression, tumor shrinkage(61.62%), thickening of the lower edge of the mandible bone, and trabecular bone formation were assessed. Six months after tumor removal, jaw morphology recovered, and the features of the mandibular second molar were preserved. No recurrence of tumor was observed in the 1 to 5 years of follow up, and the mandibular second molar functioned well.ConclusionThe fenestration and decompression technique along with tumor removal surgery to treat unicystic ameloblastoma not only reduces the disfigurement of the patient, but also preserves the function of jaw and teeth. Satisfactory clinical Results were achieved.