Tooth autotransplantation is an alternative therapeutic option for replacing the missing teeth in clinic. With the understanding of various prognosis factors, it has achieved higher survival rate. In recent years, the combination with orthodontic treatment not only extends the clinical application range, at the same time, it helps to reduce the incidence of root absorption and ankylosis of autotransplanted tooth. The purpose of this article is to review the prognosis factors influencing the success of autotransplanted tooth and the combination with orthodontic treatment.