Silver nanoparticle is a novel antibacterial agent produced by nanotechnology research. This nanoparticle is widely used in various fields for its remarkable antibacterial effect compared with those of traditional inorganic antibacterial agents. Silver nanoparticle also presents considerable safety, lasting efficacy and a long-term antimicrobial effect. In this review, we mainly describe the antibacterial mechanism and characteristics of silver nanoparticles and related research on the prevention of infectious microbial diseases and treatment of oral cavity.