口腔鳞状细胞癌患者唾液和血清中N-α-乙酰基转移酶10的水平及其临床意义
Level of N-α-acetyltransferase 10 in saliva and serum of patients with oral squamous cell carcinoma and its clinical significance
作者：余芯乐, 郑军, 徐江, 曾妍
Author：Yu Xinle, Zheng Jun, Xu Jiang, Zeng Yan
收稿日期：2017-11-25 年卷（期）页码：2018,45(4):391-395
期刊名称：国际口腔医学杂志
Journal Name：International Journal of Stomatology
关键字：口腔鳞状细胞癌,唾液,血清,N-α,-乙酰基转移酶,酶联免疫吸附测定,
Key words：oral squamous cell carcinoma,saliva,serum,N-α,-acetyltransferase,enzyme-linked immunosorbent assay,
基金项目：
国家自然科学基金（81560473）; 兵团基金资助项目（201- 4BB021,2015AD003）; 重点实验室开放基金（KF2018-5）
中文摘要
目的 探讨N-α-乙酰基转移酶10（Naa10）在口腔鳞状细胞癌患者和正常人的唾液和血清中的水平及其临床意义。方法 应用酶联免疫吸附测定（ELISA）法检测口腔鳞状细胞癌患者和正常人的唾液和血清中Naa10的水平,并分析Naa10水平与口腔鳞状细胞癌患者年龄、性别、族别、分化程度、临床分期、肿瘤转移等临床参数的相关性,绘制接受者操作特征（ROC）曲线评价唾液、血清中Naa10水平在口腔鳞状细胞癌诊断中的应用价值。结果 口腔鳞状细胞癌患者的唾液和血清中Naa10水平均高于正常对照组。无论是口腔鳞状细胞癌患者还是正常人,唾液中Naa10水平都高于血清中。口腔鳞状细胞癌患者血清中Naa10水平在不同年龄组的差异具有统计学意义（PP结论 检测唾液和血清中的Naa10水平可用于协助诊断口腔鳞状细胞癌,且其在唾液中的灵敏度和特异度更优于血清。唾液中Naa10水平与分化程度相关,可能为判断口腔鳞状细胞癌恶性程度提供帮助。
英文摘要
ObjectiveTo detect the level of N-α-acetyltransferase 10 (Naa10) in the saliva and serum of patients with oral squamous cell carcinoma (OSCC) and normal adults, and to explore its clinical significance.MethodsUsing enzyme-linked immunosorbent assay (ELISA) to detect the levels of Naa10 in the serum and saliva of OSCC patients and normal adults, the correlation between the level of Naa10 and age, gender, nationality, histological grade, clinical stage and tumor metastasis were analyzed. To evaluate the value of salivary and serum Naa10 in the diagnosis of OSCC by receiver operating characteristic (ROC) curve.ResultsThe levels of Naa10 in saliva and serum of patients with OSCC were higher than those in normal controls. In both patients with OSCC and normal controls, salivary Naa10 was higher than serum Naa10. Level of Naa10 in serum was correlated with the age of OSCC patients (PPConclusionDetection of Naa10 levels in saliva and serum is useful in diagnosis of OSCC, and its sensitivity and specificity in saliva are better than those in serum. The level of Naa10 in saliva is related to the degree of differentiation, which may help to determine the degree of malignancy of OSCC.
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