铜催化芳基乙烯与胺基磺酰氯偶联合成反式烯基磺酰胺
Synthesis of trans-ethenesulfonamides in copper-catalyzed direct cross-coupling of arylethenes with sulfamoyl chlorides
作者：陈长友;易东;韦思平;付强;
Author：
收稿日期： 年卷（期）页码：2019,34(01):-10-14
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：芳基乙烯;胺基磺酰氯;反式烯基磺酰胺;铜;催化;偶联;操作简便;选择性;合成
Key words：
基金项目：
中文摘要
目的建立一种便捷、选择性合成反式烯基磺酰胺类化合物的方法。方法在溴化亚铜催化下,以1,10-菲咯啉为配体,碱为碳酸铯,溶剂为二氯甲烷,在50℃下,于敞开的容器中反应0. 5 h,芳基乙烯与胺基磺酰氯能以35%～57%的收率转化为相应的反式烯基磺酰胺类化合物。结果制备了一系列结构多样的反式烯基磺酰胺类化合物,结构经1HNMR和13CNMR表征。结论该反应原料易得、条件温和、操作简便、底物适用范围广、选择性高。
参考文献
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