Dess-Martin试剂促进吲哚硫醚合成反应的研究
Study on the synthesis of sulfenylindoles with Dess-Martin periodinane-promoted
作者：杨路;陈粟源;易东;付强;梁武;张智杰;杜锋田;姬建新;曾庆乐;
Author：
收稿日期： 年卷（期）页码：2018,33(01):-8-12
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：Dess-Martin试剂;促进剂;硫醇;吲哚;吲哚硫醚;合成
Key words：
基金项目：
中文摘要
目的建立简单、高效制备吲哚硫醚类化合物的方法。方法以Dess-Martin试剂(DMP)为促进剂,异丙醇为溶剂,在室温下反应15 min,促进硫醇和吲哚反应来制备吲哚硫醚类化合物。结果和讨论合成了一系列吲哚硫醚类化合物,结构经~1HNMR、~(13)CNMR和HR-MS鉴定。该反应具有原子经济性好、反应条件温和、反应时间短等优点。
参考文献
[1]Funk CD.Leukotriene modifiers as potential therapeutics for cardiovascular disease[J].Nat Rev Drug Discov,2005,4(8):664-672.
[2]Xiao FH,Xie H,Liu S,et al.Iodine-catalyzed regioselective sulfenylation of indoles with sodium sulfinates[J].Adv Synth Catal,2014,356(2-3):364-368.
[3]Liu XX,Cui HH,Yang DS,et al.Iodine-catalyzed direct thiolation of indoles with thiols leading to 3-thioindoles using air as the oxidant[J].Catal Lett,2016,146(9):1743-1748.
[4]Liu YY,Zhang Y,Hu CF,et al.Synthesis of 3-sulfenylated indoles by a simple Na OH promoted sulfenylation reaction[J].Rsc Adv,2014,4(67):35528-35530.
[5]Yoshimura A,Zhdankin VV.Advances in synthetic applications of hypervalent iodine compounds[J].Chem Rev,2016,116(5):3328-3435.
[6]Hu DY,Li MS,Zhong WW,et al.Direct synthesis of alphahydroxyketone phosphates from terminal alkynes and H-phosphine oxides in the presence of Ph I(OAc)2and H2O[J].Chinese Chem Lett,2016,27(11):1691-1695.
[7]Li MS,Zhang Q,Hu DY,et al.Catalyst-free direct difunctionalization of alkenes with H-phosphine oxides and dioxygen:A facile and green approach to beta-hydroxyphosphine oxides[J].Tetrahedron Lett,2016,57(24):2642-2646.
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