Rh阴性抗-D人免疫球蛋白的研究进展
Research advance of anti-D immuneglobulin( human)
作者：罗观文;梁栋立;洪好武;陈庆立;骆燕容;胡川;
Author：
收稿日期： 年卷（期）页码：2019,34(02):-179-182
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：抗-D人免疫球蛋白;孤儿药;Rh-D血型;新生儿和胎儿溶血病;血小板减少性紫癜;制备工艺;作用机制;临床应用;研究进展
Key words：
基金项目：广东省科技厅项目(粤科高字2011-115号)
中文摘要
Rh阴性抗-D人免疫球蛋白(Anti-D IVIG)是一种冻干血浆免疫球蛋白制剂,包含高效价的抗-D抗体。其在防止Rh D血型不合所致的新生儿和胎儿溶血病(HDFN)方面发挥着不可替代的作用,同时,作为特发性血小板减少性紫癜的一线治疗药物,临床应用前景广泛,国内尚无相关产品上市。现就Anti-D IVIG制品的制备工艺、作用机制及临床应用的研究进展进行综述。
参考文献
[1]王颖,刘婷婷,许志远,等.RhD阴性孕妇注射抗-D免疫球蛋白后新生儿直接抗人球蛋白试验阳性1例[J].北京医学,2018,40(6):586-587.
[2]泥永安,刘壮.抗-D免疫球蛋白治疗儿童特发性血小板减少性紫癜研究进展[J].实用儿科临床杂志,2012,27(3):221-223.
[3]Neunert C,Lim W,crowther M,et al.The american society of hematology 201l evidence-based practice guideline for immune thmmbocytopenia[J].Blood,2011,117(16):4190-4207.
[4]吕献忠,孔冬冬.抗D免疫球蛋白的制备方法[P].中国102816237A.2012-12-12.
[5]石明隽,谢竞,钟江,等.用RhD阳性红细胞从含抗D抗体的Ig G中提纯抗D抗体[J].中国免疫学杂志,2017,11(1):1012-1014.
[6]Serge ED,Arend M,Onno JHM.Verhagen.Production of recombinant Ig molecules from antigen-selected single Bcells and restricted usage of Ig-gene segments by anti-Dantibodies[J].J Immunological Methods,2005,298:9-20.
[7]Stasi R.Rozrolimupab,symphobodies against rhesus D,for thepotential prevention of hemolytic disease of the newborn and the treatment of idiopathic thrombocytopenic purpura[J].Curr Opin Mol Ther,2010,12(6):734-740.
[8]张京,卢新,孙璇,等.抗D免疫球蛋白在Rh阴性血型孕产妇中的应用效果[J].中国医药导报,2018,15(10):135-138.
[9]Harkness M,Freer Y,Warner P.Midwives’experience of offering anti-D immunoglobulin to women:The importance of choice[J].British J Midwifery,2016,24(7):500-505.
[10]Qureshi H,Massey E,Kirwan D,et a1.BCSH guideline for the use of anti-D immunoglobulin for the prevention of haemolytic disease of the fetus and newborn[J].Transfus Med,2014,24(1):18-20.
[11]Semple IW,Allen D,Rutherford M,et al.Anti-D(WinRho-SD)treatment of children with chronic autoimmune thrombocytopenic purpura stimulates transient cytokine/chemokine production[J].Am J Hematol,2012,69:225-227.
[12]Zimmerman SA,Malinoski FJ,Ware RE.Immunologic effects of anti-D(WinRho-SD)in children with autoimmune thrombocytopenic purpura[J].Am J Hematol,1998,57:131-138.
[13]Moise KJ,Argoti PS.Management and prevention of red cellalloimmunization in pregnancy:A systematic review[J].Obstet Gynecol,2012,120(5):1132-1139.
[14]包碧惠,徐忠兰,陈芹等.胎婴儿Rh溶血病的临床诊治进展[J].西南军医,2017,19(3):279-281.
[15]刘巧英,高丽萍,翟锦娣,等.孕期RH血型不合孕妇应用抗D免疫球蛋白治疗20例临床研究[J].齐齐哈尔医学院学报,2016,37(19):2387-2388.
[16]De MH,Thurik FF,Van CDP,et al.Sensitivity of fetal RHDscreening for safe guidance of targeted anti-Dimmunoglobulin prophylaxis:Prospective cohort study of a nationwide programme in the Netherlands[J].Obste Gynecol Surv,2016,355(3):5789.
[17]Yousuf R,Mustafa AN,Ho SL,et al.Anti-G with concomitant anti-C and anti-D:A case report in a pregnant woman[J].Asian J Transfusion Sci,2017,11(1):62-63.
[18]王满妮,吴大洲,左琴琴,等.弱D-5型D抗原同种免疫的分析研究[J].中国输血杂志,2013,26(10):968-969.
[19]金呈强,董海新,刘仿,等.急性特发性血小板减少性紫癜患儿外周瓶血小板相关抗体和白细胞介素18的检测[J].新乡医学院学报,2010,27(1):48-51.
[20]覃薇,黄少玲,李婷婷,等.抗-D免疫球蛋白治疗儿童免疫性血小板减少症疗效的Mate分析[J].中国当代儿科杂志,2017,19(10):1070-1076.
[21]Essam HI.Evaluation of BioVue column agglutination technology for quality control purpose of therapeutic anti-Rh immunoglobulin preparations[J].J King Saud University,2010,22(1):209-212.
【关闭】
