模拟低氧环境对对乙酰氨基酚药动学的影响
Effect of the simulated high altitude hypoxia on pharmacokinetics of Acetaminophen
作者：年永琼;辛元尧;杨建鑫;朱琳;刘贵琴;李向阳;
Author：
收稿日期： 年卷（期）页码：2019,34(02):-141-146
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：对乙酰氨基酚;模拟低氧环境;药代动力学;SD大鼠;高效液相色谱法;血药浓度;急性低氧;慢性低氧
Key words：
基金项目：国家自然科学基金资助项目(批准号:81760673、81460568)
中文摘要
目的研究对乙酰氨基酚在模拟低氧条件下药代动力学特征的变化,为其在高原环境下的临床应用提供理论依据。方法将SD大鼠分为平原组(常氧条件饲养)、急性缺氧组(低压氧舱连续饲养4 d)和慢性缺氧组(低压氧舱连续饲养30 d) 3组。大鼠灌胃给药后,在10 min及0. 5、1、1. 5、2、3、4、6、8、12 h时于眼底静脉取血,采用HPLC法测定血浆中对乙酰氨基酚的浓度,计算药动学参数。结果与平原组大鼠相比,急性低氧组和慢性低氧组的t_(1/2)、MRT、AUC、C_(max)增加,CL、Vd、ke减小。结论在低氧环境中,对乙酰氨基酚的代谢减慢。
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