速释型溴隐亭治疗2型糖尿病患者有效性的系统评价
作者：樊萍;秦舟;高洋洋;何璐璐;郑明琳;徐珽;
Author：
收稿日期： 年卷（期）页码：2018,33(04):-450-453
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：速释型溴隐亭;2型糖尿病;系统评价;计算机检索;随机对照试验;Meta分析;糖化血红蛋白;餐后血糖
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基金项目：
中文摘要
系统评价速释型溴隐亭用于治疗2型糖尿病患者的有效性,以期为其在临床上的使用提供循证参考。采用计算机检索CENTRAL、Pub Med,Medline、Embase、中国知网、维普数据库和万方数据库,收集速释型溴隐亭或速释型溴隐亭合并其他降糖药物治疗2型糖尿病的的随机对照试验(RCT),提取资料并进行质量评价后,采用Rev Man 5.3统计软件进行Meta分析。最终纳入9篇RCT,合计9309例患者。Meta分析显示:速释型溴隐亭组患者经治疗,糖化血红蛋白较安慰剂组下降更明显,空腹血糖较安慰剂组下降更明显,餐后血糖较安慰剂组下降不明显。速释型溴隐亭并未增加患者心血管疾病的风险。速释型溴隐亭对2型糖尿病患者的降糖效果明显,由于国内该药并未批准治疗2型糖尿病的适应症,临床上使用仍需谨慎。
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