茴三硫对利福平致药物性肝损伤的保护作用及机制
Protective effects and mechanism of Anethole trithione on the rats with drug-induced liver injury caused by Rifampicin
作者：叶晓莉;王凌;蒋学华;
Author：
收稿日期： 年卷（期）页码：2018,33(05):-501-503
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：利福平;茴三硫;药物性肝损伤;胆汁淤积;多药耐药相关蛋白2;碱性磷酸酶;总胆红素;胆汁酸;作用机制
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基金项目：
中文摘要
目的研究茴三硫对利福平所致药物性肝损伤的保护作用,并初步研究其机制。方法将♂SD大鼠随机均分为对照组、模型组、茴三硫低、中、高剂量(5、10、25 mg·kg~(-1))组;观察大鼠肝脏组织的病理切片,测定肝功能生化指标和血清中胆汁酸的水平;采用q PCR实验检测大鼠肝脏组织中多药耐药相关蛋白2(Mrp2)mRNA的表达水平。结果与模型组比较,茴三硫显著地减少了大鼠肝脏组织中变性或坏死的肝细胞,未见明显肝脏病变;显著地降低了血清中碱性磷酸酶(ALP)、总胆红素(TBIL)、胆汁酸的水平;显著地提高了肝脏组织中Mrp2 mRNA的表达水平,且呈剂量依赖性。结论茴三硫对利福平所致药物性肝损伤具有保护作用,其保肝、利胆作用的机制可能与上调肝脏组织中Mrp2的表达水平,减少胆汁淤积有关。
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