注射用亚锡三乙烯四胺六亚甲基膦酸药盒的制备与分析
Preparation and analysis of the kits with the triethylene tetramine hexamethylene phosphonate and stannous chloride for injection
作者:王关全;宋虎;卓连刚;李兴亮;郭继军;魏洪源;
Author:
收稿日期: 年卷(期)页码:2018,33(05):-470-473
期刊名称:华西药学杂志
Journal Name:WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字:放射性药物;~(99m)Tc;三乙烯四胺六亚甲基膦酸;亚锡;药盒;氧化还原电位滴定法;稳定性
Key words:
基金项目:国家科技重大专项资助项目(2014ZX09507007-004)
中文摘要
目的制备注射用亚锡三乙烯四胺六亚甲基膦酸(TTHMP)药盒,并考察其稳定性。方法采用放射性~(99m)Tc标记和KIO_3氧化还原电位滴定法测定注射用亚锡TTHMP药盒中亚锡和TTHMP的用量;采用电位滴定法检测亚锡的限量值。结果确定了药盒中亚锡及TTHMP的用量分别为0. 5、5. 0 mg,所制备药盒的~(99m)Tc-TTHMP标记率可达98%;用电位滴定法测定亚锡含量时,KIO_3(1. 667 mmol·L~(-1))的消耗量应≥0. 06 mL;药盒在12个月内质量稳定。结论所制备注射用亚锡TTHMP药盒的~(99m)Tc-TTHMP标记率高,质量稳定,可满足对~(99m)Tc标记放射性药物的要求。
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