姜黄素纳米乳的体内外药动学研究
Pharmacokinetics study of curcumin nanoemulsion in vitro and in vivo
作者：杨梅;张景勍;王红;万坤;万胜利;胡雪原;
Author：
收稿日期： 年卷（期）页码：2016,31(02):-174-177
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：姜黄素;纳米乳;体外;体内;药代动力学;生物利用度
Key words：
基金项目：重庆市教委基金项目(编号:KJ120321)
中文摘要
目的研究姜黄素纳米乳的体内外药动学,并与游离的药物比较。方法用透析法考察姜黄素纳米乳体外释放药物的特点,建立大鼠模型研究其在体内的吸收情况。结果姜黄素纳米乳和游离姜黄素在0.1 mol·L-1盐酸和p H6.8磷酸缓冲溶液中的释药符合Higuchi模型,纳米乳的释放曲线在各种释放介质中与游离药物的相似因子均小于50;而姜黄素纳米乳的Ka和Papp在不同肠段与游离药物的相比均提高了约2倍,AUC(0-72)约是游离药物的4倍。结论姜黄素纳米乳较游离药物提高了药物的生物利用度。
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