天门冬酰胺酶羟丙基-β-环糊精脂质体的稳定性及相关机制的初步研究
Preliminary study on the stability and related mechanism of L-asparaginase loaded in hydroxypropyl-β-cyclodextrin liposomes
作者：万胜利;李瑶;何丹;晏子俊;张景勍;
Author：
收稿日期： 年卷（期）页码：2017,32(02):-157-159
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：天门冬酰胺酶;羟丙基-β-环糊精脂质体;稳定性;逆相蒸发法;机制
Key words：
基金项目：国家自然科学基金资助项目(批准号:30973645)
中文摘要
目的考察天门冬酰胺酶(L-Asp)羟丙基-β-环糊精脂质体(AHL)的稳定性及相关机制。方法采用逆相蒸发法制备AHL,对其低温放置稳定性、热稳定性、酸碱稳定性、血浆稳定性、抗胰蛋白酶水解能力及相关机制进行初步研究。结果 AHL体外稳定性都优于L-Asp,能阻止L-Asp构象的改变。结论 AHL能提高L-Asp的稳定性。
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