异硫氰酸苄基酯包合物胃漂浮片的制备
Preparation of Stomach buoyant tablets containing benzyl isothiocyanate inclusions
作者：王家平;刘建强;肖韵;李福美;李宝红;
Author：
收稿日期： 年卷（期）页码：2017,32(02):-135-138
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：异硫氰酸酯苄基酯;包合技术;胃漂浮片;刺激性气味
Key words：
基金项目：东莞市科技计划重点项目(2012108101010);;
广东医学院博士学位人员科研启动项目(B2014009)
中文摘要
目的掩盖异硫氰酸苄基酯的刺激性气味,提高稳定性,延长其在体内的作用时间。方法先采用饱和水溶液法将异硫氰酸苄基酯用2-羟丙基-β-环糊精包合,再以HPMC为主的凝胶骨架材料将该包合物制备成胃漂浮片,采用正交设计优化处方。结果得到包封率为80%的包合物,以及在模拟人工胃液中能立即起漂且持漂时间达8 h的胃漂浮缓释片剂。结论制备的异硫氰酸苄基酯包合物胃漂浮片的漂浮性能良好,且能掩盖其刺激性气味,达到缓释效果。
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