荨麻总黄酮对记忆障碍模型小鼠学习记忆能力的影响
Influence of total Urtica flavonoids on learing memory behavior in the learning disorder and dysmnesia model mice
作者：景波;吕程;于建;叶强;叶壮琳;殷中琼;
Author：
收稿日期： 年卷（期）页码：2016,31(03):-239-242
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：小鼠;荨麻;总黄酮;八臂迷宫试验;学习;记忆;抗氧化;抗衰老
Key words：
基金项目：国家自然科学基金资助项目(批准号:31372477);;
四川农业大学本科论文培育计划资助项目
中文摘要
目的研究荨麻总黄酮(TUF)对记忆障碍模型小鼠学习记忆能力的影响。方法预防性给予小鼠TUF后,用不同方法模拟小鼠记忆获得障碍模型,行八臂迷宫试验;通过小鼠体重变化、负重游泳试验及血清和脑中总抗氧化能力(T-AOC)和超氧化物歧化酶(SOD)水平的变化,评估TUF的抗衰老、抗氧化作用。结果 TUF可显著改善东莨菪碱、氯霉素、40%乙醇对小鼠记忆行为能力的影响;增强D-半乳糖致衰老模型小鼠的记忆力,维持正常增重及延长负重游泳时间,还可显著提高衰老小鼠的抗氧化能力。结论 TUF可有效改善记忆障碍模型小鼠的记忆力,这可能与其抗氧化能力有关。
参考文献
[1]Abedi G F,Abedi G Y,Moazenzade K O,et al.Effects of a triplex mixture of Peganum harmala,Rhus coriaria,and Urtica dioica aqueous extracts on metabolic and histological parameters in diabetic rats[J].Pharm Biol,2015,23:1-6.
[2]唐玲,冀保全,史现颖,等.荨麻抗类风湿性关节炎的实验研究[J].华西药学杂志,2008,23(5):552-555.
[3]Antunes MS,Goes AT,Boeira SP,et al.Protective effect of hesperidin in a model of Parkinson's disease induced by 6-hydroxydopamine in aged mice[J].Nutrition,2014,30(11-12):1415-1422.
[4]H.G.沃格尔,W.H.沃格尔,编著.杜冠华,李学军,张永祥,等译.药理学实验指南—新药发现和药理学评价[M].北京:科学出版社,2001:456-457.
[5]Anzoise ML,Marrassini C,Ferraro G,et al.Hydroalcoholic extract of Urtica circularis:A neuropharmacological profile[J].Pharm Biol,2013,51(10):1236-1242.
[6]Baker RC,Kramer RE.Cytoxicity of short-chain alcohols[J].Annu Rev Pharmacol Toxicol,1999,39:127-150.
[7]Moneim AE.Oxidant/Antioxidant imbalance and the risk of Alzheimer's disease[J].Curr Alzheimer Res,2015,12(4):335-349.
[8]Takahashi R,Komiya Y,Goto S.Effect of dietary restriction on learning and memory impairment and histologic alterations of brain stem in senescence-accelerated mouse(SAM)P8 strain[J].Ann N Y Acad Sci,2006,1067:388-393.
[9]Patel SS,Parashar A,Udayabanu M.Urtica dioica leaves modulates muscarinic cholinergic system in the hippocampus of streptozotocin-induced diabetic mice[J].Metab Brain Dis,2015,30(3):803-811.
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