虎杖中白藜芦醇及其甲基化衍生物对高脂血症小鼠降血脂和抗氧化作用的研究
Effect of resveratrol and its methylated derivatives in Polygonurn cuspidatum on hyperlipidemia mice by inhibition of lipid peroxidation
作者：李朋;陈萍;张浩;
Author：
收稿日期： 年卷（期）页码：2016,31(04):-374-377
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：白藜芦醇衍生物;虎仗;氧化性低密度脂蛋白;一氧化氮;高脂血症
Key words：
基金项目：
中文摘要
目的比较虎杖中白藜芦醇、3,4'-二甲基化白藜芦醇、3,5,4'-三甲基白藜芦醇对高脂饲养小鼠动脉粥样硬化作用的影响。方法小鼠用高脂饲料喂养8周,从第5周开始,给予白藜芦醇组、3,4'-二甲基化白藜芦醇组、3,5,4'-三甲基白藜芦醇组单日单剂量30 mg·kg~(-1),阳性对照组10 mg·kg~(-1)辛伐他丁,通过测定小鼠血清中一系列参数来判断白藜芦醇及其甲基化衍生物在降血脂和抗氧化方面的效果。结果白藜芦醇及其甲基化衍生物均能显著降低小鼠血清中TG、TC、LDL-C、oxLDL、MDA的含量(P
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