中草药来源的5α-还原酶抑制剂的研究进展
作者:唐青涛;
Author:
收稿日期: 年卷(期)页码:2016,31(05):-544-547
期刊名称:华西药学杂志
Journal Name:WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字:中草药;5α-还原酶;抑制剂;睾酮;二氢睾酮;雄激素依赖型疾病;雄激素性脱发;非那雄胺
Key words:
基金项目:
中文摘要
抑制5α-还原酶可降低雄激素水平从而治疗雄激素依赖型疾病。中草药在有效阻止雄激素依赖型疾病发生和改善症状方面显示了良好的应用潜力。现综述近几年中草药来源5α-还原酶抑制剂的研究进展。
参考文献
[1]Russell DW,Wilson JD.Steroid 5 alpha-reductase:Two genes/two enzymes[J].Annu Rev Biochem,1994,63:25-61.
[2]Bruchovsky N,Wilson JD.The conversion of testosterone to 5-alpha-androstan-17-beta-ol-3-one by rat prostate in vivo and in vitro[J].J Biol Chem,1968,25,243(8):2012-2021.
[3]Sun J.Recent advances in research on nonsteroidal 5α-reductase inhibitors[J].Prog Pharm Sci,2011,35:450-455.
[4]Li X,Chen C,Singh SM,et al.The enzyme and inhibitors of 4-ene-3-oxosteroid 5-oxidoreductase[J].Steroids,1995,60:430-441.
[5]Uemura M,Tamura K,Chung S,et al.Novel 5 alpha-steroid reductase(SRD5A3,type-3)is overexpressed in hormonerefractory prostate cancer[J].Cancer Sci,2008,99(1):81-86.
[6]Banday AH,Shameem SA,Jeelani S.Steroidal pyrazolines and pyrazoles as potential 5α-reductase inhibitors:Synthesis and biological evaluation[J].Steroids,2014,92:13-19.
[7]况刚.以5α-还原酶为靶点研究肉豆蔻改善良性前列腺增生的作用[D].成都:成都中医药大学硕士学位论文,2005.
[8]车璐.香水莲花抗氧化及抑制5a-还原酶的研究[D].杭州:浙江大学硕士学位论文,2013.
[9]罗晓伟.油茶蒲醇提物抑制5α-还原酶及对前列腺疾病的作用[D].杭州:浙江大学硕士学位论文,2011.
[10]孙弘.从油菜花粉中筛选5α还原酶抑制剂[D].武汉:湖北中医学院硕士学位论文,2009.
[11]李蓉,秦坚民,余国奠.荨麻属药用植物研究概况及其开发价值[J].中国野生植物资源,2002,21(1):24-26.
[12]赵齐,张雯雯,卢轩,等.宽叶荨麻提取物抑制5α-还原酶作用的研究[J].沈阳中医药大学学报,2014,(31):70-73.
[13]刘向慧,王琪,宋丽雅,等.鹰嘴豆素A对病理脱发模型小鼠毛发生长影响的初步研究[J].天然产物研究与开发,2014,26:613-618.
[14]Fujita R,Liu J,Shimizu K,et al.Anti-androgenic activities of Ganoderma lucidum[J].J Ethnopharmacol,2005,102:107-112.
[15]Liu J,Kurashiki K,Shimizu K,et al.5α-reductase inhibitory effect of triterpenoids isolated from Ganoderma lucidum[J].Biol Pharm Bull,2006,29(2):392-395.
[16]Liu J,Shiono J,Shimizu K,et al.Ganoderic acid DM:Antiandrogenic osteoclastogenesis inhibitor[J].Bioorg Med Chem Lett,2009,19:2154-2157.
[17]王毓平,李小林,刘永青,等.车前子提取物抑制大鼠前列腺增生及对5α-还原酶的影响[J].中国老年学杂志,2013,33(15):3643-3646.
[18]巫传玲,马松涛,王富琴,等.莲子心提取物对5α-还原酶的抑制作用研究[J].中国药业,2012,21(10):17-18.
[19]喻凯.紫檀浸膏对5α-还原酶的抑制作用[J].华西药学杂志,2007,22(5):506-507.
[20]Kim J,Han J.Steroid 5α-reductase inhibition by polymethoxyflavones[J].J Korean Soc Appl Biol Chem,2013,56(4):469-471.
[21]Murata K,Noguchi K,Kondo M,et al.Inhibitory activities of Puerariae Flos against testosterone 5α-reductase and its hair growth promotion activities[J].J Nat Med,2012,66(1):158-165.
[22]陈磊,郑清明,郑汉臣,等.蜘蛛香的研究进展[J].中国野生植物资源,2002,21(1):8-11.
[23]肖丹.蜘蛛香提取物抗良性前列腺增生的作用及机理研究[D].成都:成都中医药大学博士学位论文,2005.
[24]何银,徐真真,冯霞,等.石榴皮提取物对小鼠实验性前列腺增生的影响[J].中药新药与临床药理,2009(20):102-106.
[25]Cho CH,Bae JS,Kim YU.5alpha-reductase inhibitory components as antiandrogens from herbal medicine[J].J Acupunct Meridian Stud,2010,3(2):116-118.
[26]Akamine K,Koyama T,Yazawa K.Banana peel extract suppressed prostate gland enlargement in testosterone-treated mice[J].Biosci Biotechnol Biochem,2009,73(9):1911-1914.
[27]Murata K,Takeshita F,Samukawa K,et al.Effects of Ginseng rhizome and ginsenoside Ro on testosterone 5α-reductase and hair re-growth in testosterone-treated mice[J].Phytother Res,2012,26(1):48-53.
[28]Pandit S,Chauhan NS,Dixit VK.Effect of Cuscuta reflexa Roxb.on androgen-induced alopecia[J].J Cosmet Dermatol,2008,7(3):199-204.
[29]Andriole GL,Kirby R.Safety and tolerability of the dual 5α-reductase inhibitor dutasteride in the treatment of benign prostatic hyperplasia[J].Eur Urol,2003,44:82-88.
【关闭】