L-阿拉伯吡喃糖1,2-cis-糖苷化反应的研究
Research of L-arabinopyranosyl 1,2-cis-glycosylation
作者：曹辉;杨劲松;
Author：
收稿日期： 年卷（期）页码：2016,31(05):-448-450
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：L-阿拉伯吡喃糖;乙硫苷供体;1,2-cis-糖苷化反应;合成;溶剂效应;远程参与效应
Key words：
基金项目：国家自然科学基金资助项目(批准号:21372166)
中文摘要
目的设计一个合理有效的供体来构建L-阿拉伯吡喃糖1,2-cis-苷键。方法以L-阿拉伯糖为原料,制备了3个乙硫苷供体,在不同温度、溶剂条件下,对供体进行糖苷化反应的考察。结果 3,4-位双苯甲酰基取代的供体Ⅱa以最佳的立体选择性和收率得到β-糖苷化产物,产物的结构经1HNMR分析确证。结论所用方法的条件温和、操作简便、立体选择性好、收率高。
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