铜纳米颗粒催化合成3-取代异香豆素及其衍生物
Synthesis of 3-substituted isocoumarins and its derivatives by copper nanoparticles catalyst
作者：范兴风;王德才;王鑫;高瑞;
Author：
收稿日期： 年卷（期）页码：2017,32(06):-573-575
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：铜纳米颗粒;3-取代异香豆素;衍生物;催化;合成
Key words：
基金项目：
中文摘要
目的制备3-取代异香豆素及其衍生物。方法以邻卤代苯甲酸为起始原料,通过卤化、酰胺化,得N-苯基-2-卤代苯甲酰胺衍生物,在铜纳米颗粒催化下与1,3-二羰基化合物反应,得到目标化合物。结果合成了3-取代异香豆素,其结构经1HNMR和ESI-MS确证。结论所用方法反应的原料简单易得、产物收率较高,可高效合成3-取代异香豆素,拓展了3-取代异香豆素的合成方法。
参考文献
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