PT多肽修饰的地塞米松纳米脂质载体的体外释放研究
Study on the release characteristics of PT peptide grafted Dexamethasone nanostructured lipid carriers in vitro
作者：邹国芳;赵春艳;谢向群;黄园;简炎林;
Author：
收稿日期： 年卷（期）页码：2013,28(01):-71-72
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：地塞米松;PT多肽修饰;纳米脂质载体;体外释放
Key words：
基金项目：深圳市科技计划资助项目(编号:201002046)
中文摘要
目的研究PT多肽修饰的地塞米松纳米脂质载体的体外释放规律。方法选用pH7.4磷酸盐缓冲液作为释药介质,测定并绘制其体外释放曲线,并拟合释药数据。结果 PT多肽修饰的地塞米松纳米脂质载体在0.5 h的突释率为24.2%,24h药物累计释放量为88%,最佳拟合模型为Weibull方程。结论 PT多肽修饰的地塞米松纳米脂质载体的体外释放突释效应减少,具有缓释效应。
参考文献
[1]李光伟.警惕糖皮质激素治疗的副作用[J].中华内科杂志,2003,42(10):678-679.
[2]Wang MT,Jin Y,Yang YX,et al.In vivo biodistribution,anti-inflammatory,and hepatoprotective effects of liver targeting dexa-methasone acetate loaded nanostructrued lipid carriers systemp[J].Int J Nanomedi,5:487-497.
[3]XF Xu,CY Zhao,HY Yang,et al.Anti-inflammatory activity ofinjectable dexamethasone acetate loaded nanostructrued lipid car-riers[J].Drug delivery,2011,18(7):485-492.
[4]CY Zhao,Y Liu,TT Fan,et al.A novel strategy for encapsulatingpoorly soluble drug into nanostructured lipid carriers for intrave-nous administration[J].Pharma Dev Technol,2011,1-14.
[5]Gaete CG,Tsapis N,Besnard M,et al.Encapsulation of dexam-ethasone into biodegradable polymeric nanoparticles[J].Int JPharm,2007,331:153-159.
[6]Wei W,Shi SJ,Liu J,et al.Lipid nanoparticles loaded with 10-hydroxycamptothecin-phospholipid complex developed for thetreatment of hepatoma in clinical application[J].J Drug Target,2010,18:557-566.
[7]Aviral Jain,Gousia Chasoo,Shashank KS,et al.Transferrin-ap-pended PEGylated nanoparticles for temozolomide delivery tobrain:In vitro characterization[J].J Microencapsulation,2011,28(1):21-28.
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