大黄酸分散体的制备及其对糖尿病肾病大鼠肾功能的影响
Preparation of rhein solid dispersion and its effects on experimental diabetic nephropathy in rats
作者：王文永;赵媛;刘东新;冯雁君;索炜;韩刚;
Author：
收稿日期： 年卷（期）页码：2012,27(01):-32-35
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：大黄酸;固体分散体;聚乙烯吡咯烷酮;糖尿病肾病;肾功能
Key words：
基金项目：
中文摘要
目的以聚乙烯吡咯烷酮(PVP)为载体,将大黄酸制成固体分散体。观察大黄酸固体分散体对糖尿病大鼠肾功能的影响。方法采用溶剂法制备大黄酸固体分散体;对制备的固体分散体进行差热分析和红外光谱分析。采用链脲佐菌素(STZ)诱导大鼠糖尿病模型,观察大黄酸固体分散体对糖尿病肾病大鼠肾功能的影响。结果 12周后,糖尿病大鼠血中尿素氮(BUN)、内生肌酐清除率(Ccr)、24 h尿蛋白排泄量(UPE)明显升高(P
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