1,4-环己二醇与己酰胺协同增加甲硝唑对皮肤的靶向性研究
Synergistic effect of 1,4- cyclohexanediol and hexanamide to enhance skin target of metronidazole
作者：张嫣;过芳;李楠;
Author：
收稿日期： 年卷（期）页码：2014,29(01):-20-22
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：皮肤靶向;氢键;1,4-环己二醇;己酰胺;经皮吸收
Key words：
基金项目：
中文摘要
目的研究1,4-环己二醇与己酰胺联合应用对甲硝唑体外经皮渗透的影响及其作用机制。方法以猪离体皮肤为实验材料、甲硝唑为模型药物,采用Franz扩散池进行体外透皮实验,采用HPLC考察1,4-环己二醇、己酰胺单独及联合应用对药物产生的不同渗透效果。结果 1,4-环己二醇或己酰胺单独应用的处方中甲硝唑的渗透通量分别是对照处方的1.22、1.03倍,而同时含有两药处方中的通量是对照处方的0.70,皮肤中的药物含量显著高于对照处方(P
参考文献
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