丹参联合放疗抑制小鼠肺癌肿瘤血管生成的实验研究
Study on anti-angiogenesis in mice with lewis lung carcinoma by Danshen combined with radiotherapy
作者：冯俭;谢萍;孙川;秦银花;李煌;莫小宇;
Author：
收稿日期： 年卷（期）页码：2012,27(01):-27-29
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：丹参;放疗;抑瘤率;微血管密度;肺癌
Key words：
基金项目：四川省科技厅应用基础研究项目(No.2008JY0008)
中文摘要
目的探讨丹参联合放疗对小鼠Lewis肺癌肿瘤组织中微血管密度(MVD)的影响。方法建立Lewis肺癌荷瘤鼠模型后,随机分为模型组、丹参低剂量组(丹低组)、丹参高剂量组(丹高组)、放疗组、丹低+放疗组(联合1组)、丹高+放疗组(联合2组),每组各10只小鼠。各组于接种第二日起每天腹腔注射给药,连续12 d,放疗组、联合1组、联合2组于接种第7日起给予钴-60照射肿瘤局部,放疗剂量2 Gy.d-1,连续5 d。末次给药24 h后处死小鼠,剥离肿瘤组织称重,计算抑瘤率;免疫组化法检测肿瘤组织中微血管密度(MVD)。结果丹参低剂量联合放疗组的微血管密度较放疗组和丹参低剂量组明显降低(P
参考文献
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