以D-葡萄糖为载体的布洛芬脑靶向前体药物的设计与合成
Design and synthesis of Ibuprofen prodrugs for brain target delivery using D-glucose as a vector
作者：刘兴;李文浩;龚涛;
Author：
收稿日期： 年卷（期）页码：2013,28(01):-26-28
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：脑靶向;D-葡萄糖;非甾体抗炎药;合成
Key words：
基金项目：
中文摘要
目的设计并合成以葡萄糖转运体为靶细胞的脑靶向前体药物。方法将非甾体抗炎药布洛芬通过不同的桥链(1,6-己二醇和1,12-十二二醇)与D-葡萄糖通过共价键连接起来。结果成功合成了两个以D-葡萄糖为载体的脑靶向前体药物。结论目标化合物已经1HNMR、MS确证。
参考文献
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