热熔挤出技术制备茴三硫固体分散体
Preparation of Anethol trithione solid dispersions by hot-melt extrusion technology
作者：刘春晖;林巧平;祁智;王悦;许向阳;
Author：
收稿日期： 年卷（期）页码：2013,28(01):-16-19
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：茴三硫;固体分散体;Plasdone S630;Poloxamer 188;热熔挤出
Key words：
基金项目：国家科技重大专项课题(编号:2011ZX09401-008)
中文摘要
目的制备茴三硫固体分散体。方法分别以Plasdone S630和Poloxamer 188为载体,采用热熔挤出法制备了茴三硫固体分散体并考察两种载体的增溶效果,用差示扫描量热法和X射线粉末衍射法对固体分散体进行了表征,并考察了40℃/75%RH加速实验6个月时的溶出度。结果溶出率大小为:茴三硫-Plasdone S630>胆维他>茴三硫-Poloxamer 188>物理混合物,以Plasdone S630为载体时,药物以无定形或分子状态存在于固体分散体中,以Poloxamer 188为载体时,药物以晶体状态存在于固体分散体中,溶出度稳定性Plasdone S630优于Poloxamer 188。结论 Plasdone S630更适合作为热熔挤出法制备茴三硫固体分散体的载体。
参考文献
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