藁苯内酯对大鼠兴奋毒性脑损伤及认知功能障碍的影响
Effects of ligustilide on excitotoxic brain injury and cognitive deficits in the rats
作者：陈西楠;程里玲;王宇;杜俊蓉;
Author：
收稿日期： 年卷（期）页码：2014,29(02):-135-137
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：藁苯内酯;兴奋性毒性;鹅膏蕈氨酸;基底核大细胞;阿尔兹海默症
Key words：
基金项目：国家自然基金资助项目(批准号:81072636)
中文摘要
目的研究藁苯内酯(LIG)对由神经兴奋性毒素鹅膏蕈氨酸(IBO)诱导的神经行为学缺陷和神经病理学改变的影响。方法将IBO注入大鼠的基底核大细胞(NBM)中,并分为模型组、LIG组(2.5、10 mg·kg-1LIG)、假手术组(NBM内注射生理盐水);于术后24 h ig给药大鼠,每日1次,连续给药19 d;随后进行水迷宫实验及免疫组织化学检测。结果 LIG能显著改善IBO诱导NBM损伤引起的大鼠空间记忆障碍(P
参考文献
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