石蒜碱脂质纳米乳的制备及抗肿瘤活性的初步研究
Preparation and the study of antitumor activity of lycorine nanoemulsion
作者：郭扬明;杨立开;张轩邈;刘兴;龚涛;张志荣;
Author：
收稿日期： 年卷（期）页码：2013,28(02):-127-129
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：石蒜碱;脂质纳米乳;包封率;MTT法
Key words：
基金项目：
中文摘要
目的制备石蒜碱脂质纳米粒,考察体外抗肿瘤活性。方法制备石蒜碱-油酸复合物,溶剂注入法制备纳米乳,超滤法测定包封率,MTT法初步考察纳米乳的抗肿瘤活性。结果制备的纳米乳颗粒圆整均匀,形态良好,包封率为82%±1.4%,粒径为91.9±4.0 nm,PDI为0.171±0.013,Zeta电位为-50.4±5.4 mV。纳米乳较原药能更好抑制肿瘤细胞增殖。结论溶剂注入法制备的石蒜碱脂质纳米乳包封率较高,粒径大小分布均匀,较原药具有更强的抗肿瘤活性。
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