他克莫司软膏的体外透皮吸收研究
Percutaneous absorption of Tacrolimus ointment in vitro
作者：汪宏;王维;张建华;岳山岚;杨俊毅;翁星;吴蕾;包旭;
Author：
收稿日期： 年卷（期）页码：2014,29(02):-119-121
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：他克莫司软膏;体外透皮吸收;巴马香猪;反相高效液体色谱法
Key words：
基金项目：
中文摘要
目的研究他克莫司软膏对离体巴马香猪皮的透皮吸收情况,并比较他克莫司软膏的供试制剂与参比制剂的体外透皮渗透量和渗透速率。方法采用改良Franz扩散池法,用反相HPLC法定量测定接受室溶液中他克莫司浓度及皮内滞留药物。结果他克莫司经离体巴马香猪皮的透过率随时间的延长而增加;48 h内,他克莫司软膏的供试制剂与参比制剂经离体巴马香猪皮的累积透过量分别为22.87±1.31、21.61±2.26μg·cm-2,平均渗透速率分别为0.7669、0.7149μg·cm-2·h-1。结论在透皮吸收研究中,他克莫司软膏的供试制剂与参比制剂的透皮渗透程度和渗透速率差异无统计学意义。
参考文献
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