三甲基壳聚糖-维生素B_(12)偶联物的制备与表征
Preparation and characterization of N-trimethyl chitosan-Vitamin B_(12) conjugates
作者：柯志洋;程刚;朱晰;何爽;雷英;何斌;黄园;
Author：
收稿日期： 年卷（期）页码：2013,28(03):-243-245
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：三甲基壳聚糖;维生素B12;肠上皮细胞靶向;合成
Key words：
基金项目：国家自然科学基金资助项目(批准号:81173010)
中文摘要
目的合成两种具有肠上皮细胞靶向的三甲基壳聚糖-Vit B12偶联物,并测定Vit B12的修饰度。方法分别以丁二酸和PEG2000为间隔基制备三甲基壳聚糖-Vit B12偶联物。结果与结论合成了两种不同间隔基的三甲基壳聚糖-Vit B12偶联物;目标偶联物及重要中间体经1HNMR、MS和UV确证;两种偶联物中Vit B12的修饰度分别为3.3%、3.1%。
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