HPLC荧光法测定人血浆中的5-氨基水杨酸
Determination of 5-aminosalicylic acid in human plasma by HPLC-FLU
作者：王红梅;蒋学华;宋林;何毅;王凌;
Author：
收稿日期： 年卷（期）页码：2013,28(04):-409-411
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：5-氨基水杨酸;高效液相色谱荧光法;药动学;柳氮磺吡啶肠溶片
Key words：
基金项目：
中文摘要
目的采用HPLC荧光法测定人血浆中的5-氨基水杨酸,研究单剂量口服柳氮磺吡啶肠溶片后5-氨基水杨酸在中国健康受试者体内的药动学特征。方法 24名健康受试者口服500 mg柳氮磺吡啶肠溶片,采用HPLC荧光法测定血浆中5-氨基水杨酸的浓度,利用DAS 2.1.1软件计算药动学参数。结果 5.055～808.8 ng.mL-15-氨基水杨酸与峰面积比值的线性关系良好(r=0.9985),最低检测浓度为5.055 ng.mL-1,日内、日间RSD均
参考文献
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